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    Friday Séminaire 20/11/2017

    Friday Séminaire 20/11/2017

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    Séminaire de Nathalie Guérineau

    Invitée par Christian Legros

    Le 20 novembre 2017

    Un séminaire sera donné par Nathalie Guérineau, Institute of Functional Genomics, CNRS UMR5203, INSERM U1191, University Montpellier, France.

    "Stress-induced remodeling of stimulus-secretion coupling in the rat adrenal medullary tissue"

    Les étudiants de médecine/pharmacie devant valider certains modules (M1 et M2) devront impérativement venir avec leur fiche personnelle de validation des séminaires qui sera alors tamponnée.

    12h30 - 13h30
    Salle de réunion RdC, Bâtiment IBS

     secr-inserm-angers @

    In mammals, catecholamine secretion from adrenal chromaffin cells represents an ubiquitous mechanism helping the organism to cope with stressful situations. Once delivered into the blood circulation, epinephrine and norepinephrine exert multiple actions, in particular on the cardiovascular system, leading to appropriate adjustments of blood pressure and cardiac rhythm, and on the energy metabolism, enabling the organism to cope with a threat for its survival. From birth to death, catecholamine secretion undergoes continuous adjustments, allowing the organism to adapt to homeostasis changes. While an instantaneous secretion of catecholamines is beneficial to face an acute stress episode, repeated or prolonged stressful situations resulting in sustained blood catecholamine increases are detrimental for the organism and can initiate many diseases. Catecholamine secretion from adrenal chromaffin cells relies on both a neurogenic command arising from the splanchnic nerve terminals synapsing onto chromaffin cells and a local gap junction-mediated intercellular communication between chromaffin cells. In response to stressful situations (acute and/chronic stress episodes), these two intercellular pathways are remarkably remodeled, allowing the adrenal medullary tissue to adapt catecholamine secretion to the organism demand. The talk will describe the functional remodeling of the adrenal medulla stimulus-secretion coupling that occurs in response to physiological stressors (birth and cold exposure) and in response to chronic stress-related pathologies (arterial hypertension).