Séminaire de Franck Perez
Invité par Ramaroson Andriantsitohaina
Le 26 juin 2015
Un séminaire sera donné par Franck Perez, UMR 144 Institut Curie / CNRS.
Les étudiants souhaitant assister à la conférence doivent s'inscrire au préalable avant le Jeudi 25 juin à 12h00 dans la limite des places disponibles auprès de : (secr-inserm-angers @ contact.univ-angers.fr)secr-inserm-angers @ contact.univ-angers.fr (secr-inserm-angers @ contact.univ-angers.fr) en communiquant leur numéro de carte étudiante.
Afin que la participation au séminaire soit validante, il est impératif que les étudiants émargent la feuille de présence.
Pour rappel, les étudiants non inscrits ne seront pas acceptés.
12h00 - 13h00
CHU Angers - Bâtiment IBS-IRIS – Salle de conférence RDC
secr-inserm-angers@contact.univ-angers.fr
The secretory pathway stands at the core of cell physiology because it lies at the center of most of intracellular transport routes. Cells, to regulate their homeostasis, to exchange signals with the extracellular environment or migrate for example, need to address specific proteins and lipids toward specific compartment in a tightly controlled way. Golgi-dependent trafficking plays an essential role in these process but, although our knowledge about the mechanisms of intra-Golgi transport and sorting has dramatically increased over the past decade, the underlying complexity of transport routes, in term of mechanism and dynamics, is still starting to emerge. It is clear since several decades that the cytoskeleton, and in particular microtubules, play a major role in organising the Golgi complex and enabling control of intracellular transport along dedicated tracks. This is essential not only for strongly polarised cells like neurons or epithelial cells, but for virtually any eukaryotic cell. To get access to the complexity of the secretory routes, we set-up a versatile system that allows to analyse and quantify, in real-time, the transport of very diverse proteins. We use this system to draw a comprehensive map of the secretory pathway and to find specific crossroads that may be used to open novel therapeutic approaches.